Computable Virtual Population:
Resolution at its Limit
The Computable Virtual Population V4-0 and V3-x (cViP) models are high-end high-resolution posable whole-body models for biophysical and biomedical modelling and simulation, including medical implant safety assessments.
These V3-x models include more than 120 anatomical features and more than 300 tissues all together. The exhaustive list of tissues currently included is available for download. The recently released V4-0 model has more than separate 1000 tissue regions, including about 240 peripheral nerve structures.
The CAD format of the organs allows meshing at arbitrary resolution without loss of detail and small features due to repeated sampling.
All the values of our comprehensive and up-to-date database of tissue properties can be applied to the cViP models.
NEWS
The first neuro-functionalized anatomical models from our newest generation of ViP V4-0 models is now available: Yoon-sun V4-0 and Jeduk V4-0. These models have been designed to support novel neuro-stimulation investigations, e.g. MRI gradient safety and optimization of therapeutic devices.Compatibility with previous versions
The ViP 3.x models have been validated and their compatibility with the ViP 1.x models has been assessed for EM simulations: the results of MR safety and MR implant safety evaluations are statistically identical between the two versions.
| Name | Sex
|
Age |
Height1 |
Weight1 |
BMI1 |
|
male |
84 |
1.73 |
61.1 |
20.4 |
|
|
male |
38 |
1.81 |
106.0 |
32.4 |
|
|
male |
37 |
1.82 |
119 |
36 |
|
|
male |
34 |
1.77 |
70.2 |
22.4 |
|
|
male |
33 |
1.62 |
64.5 |
24.6 |
|
|
female |
26 |
1.63 |
57.3 |
21.6 |
|
|
female |
26 |
1.52 |
54.6 |
23.6 |
|
|
male |
14 |
1.68 |
49.7 |
17.6 |
|
|
female |
11 |
1.49 |
34.0 |
15.3 |
|
|
female |
8 |
1.36 |
29.9 |
16.2 |
|
|
male |
8 |
1.37 |
25.3 |
13.5 |
|
|
male |
6 |
1.16 |
18.6 |
13.8 |
|
|
female |
5 |
1.09 |
17.8 |
14.9 |
|
|
Nina2 |
female |
3 |
0.92 |
13.9 |
16.4 |
|
female |
8 weeks |
N/A |
4.3 |
N/A |
|
|
N/A |
3 months |
N/A |
0.015 |
N/A |
|
|
N/A |
7 months |
N/A |
1.4 |
N/A |
|
|
female |
9 months |
N/A |
2.7 |
N/A |
1 These values are calculated based on the latest version of the models and of the tissue properties database
2 These models exist in version 1.x only.
3 The specifications refer to the fetus. The adult model is that of Ella.
Systems Requirements
The CAD models require at least 4 GB of RAM for V1-x and 6 GB for V3-x/V4-0. Depending on the resolution of the models, the memory requirements for loading and processing the voxel models can be very high.
Distribution
Please address all inquiries about V3-x and V4.x to the Sim4Life sales team and all inquiries about V1-x to the Virtual Population Group. For downloading the models, please chose any model above to be directed to the download page.
Acknowledgements
The virtual family models were developed in cooperation with the Center for Devices and Radiological Health of the U.S. Food and Drug Administration, Silver Spring, MD, USA (FDA); the Austrian Research Centers GmbH, Seibersdorf, Austria; the University of Houston, TX, USA; the Hospital of the Friedrich-Alexander-University (FAU), Erlangen, Germany; and Siemens Medical Solutions, Erlangen, Germany.
The Mobile Manufacturers Forum, the GSM Association and SPEAG funded the development of two adult and two child models. The German Federal Office for Radiation Protection (BfS) supported the development of four additional child models. Scientists at FDA (USA) validated the models.
Contributions from The Netherlands Organization for Health Research and Development (ZonMw) supported the further development and significant improvement of the anatomical fidelity of the child models. Pediatricians at the Erasmus MC-Daniel den Hoed Cancer Center reviewed the models. The Swiss National Research Programme NRP 57 “Non-Ionising Radiation – Health and Environment” funded the development of the pregnant models.
The Korean models Yoonsun and Jeduk were created in cooperation with the Visible Korean team (anatomy departments of from Ajou University and Dongguk University ). The cryosection image data was provided by our Korean partners, within the frame of the project NEUROMAN, which received by the Swiss Commission for Technology and Innovation (CTI 25290.1 PFLS-LS) and the Korean Institute for Advancement of Technology.
The model Eddie was created based on the Visible Human cryosection image dataset provided by the US National Library of Medicine (NLM). The segmentation was partly funded by SPEAG.
References for citation
The Virtual Family – Development of Surface-based Anatomical Models of Two Adults and Two Children for Dosimetric Simulations
Andreas Christ, Wolfgang Kainz, Eckhart G. Hahn, Katharina Honegger, Marcel Zefferer, Esra Neufeld, Wolfgang Rascher, Rolf Janka, Werner Bautz, Ji Chen, Berthold Kiefer, Peter Schmitt, Hans-Peter Hollenbach, Jianxiang Shen, Michael Oberle, Dominik Szczerba, Anthony Kam, Joshua W. Guag and Niels Kuster, in Physics in Medicine and Biology, Volume 55, Issue 2, pp. N23–N38, January 2010
Development of a New Generation of High-Resolution Anatomical Models for Medical Device Evaluation: The Virtual Population 3.0
Marie-Christine Gosselin, Esra Neufeld, Heidi Moser, Eveline Huber, Silvia Farcito, Livia Gerber, Maria Jedensjo, Isabel Hilber, Fabienne Di Gennaro, Bryn Lloyd, Emilio Cherubini, Dominik Szczerba, Wolfgang Kainz and Niels Kuster, in Physics in Medicine and Biology, Volume 59, Issue 18, pp. 5287–5303, June 2014
