Precision Medicine



Patient MRI image (greyscale) is segmented to form a high resolution 3D tissue-mapped model positioned within an applicator. The model is voxeled (false color) and an electro-thermal exposure simulation performed (heat map)



HIFU transducer array creating a thermal hot spot deep in the brain for tissue ablation during noninvasive brain surgery.

Precision Medicine

Expertise & Infrastructure

The IT'IS Foundation has dedicated an interdisciplinary team of software engineers, biologists, and radiologists to refining and expanding its database of anatomical models, developing solvers to deal specifically with complex, heterogeneous living tissue, and to develop tools to transform patient medical image data (MRI, CT, etc.) into detailed 3D models through image segmentation, accelerated by image registration of previously segmented models (e.g., the Virtual Population). Modeling is then supported by automatic assignment of tissue properties from the IT'IS database.

With more than 100 Sim4Life licenses, including the Virtual Population 3.x/4.x and multiple animal models, and several High Performance Computers (HPC) ranging from Graphics Processing Unit (GPU) clusters to supercomputers, our interdisciplinary research team can tackle highly specific and complex research tasks with superior innovation and efficiency – while ensuring compliance to national and international standards.


Select Customized Research Projects of the Past Years
  • Developed a comprehensive platform for personalized treatment planning in hyperthermic oncology, deployed in a range of major hospitals;
  • Developed a simulation platform for image-based optimization of focused ultrasound (FUS) therapies (functionalized neurosurgery, cancer ablation, reversible blood-brain barrier opening);
  • Supported multiple companies in the successful design of novel applicators for thermal therapies, with superior targeting and control capabilities;
  • Developed tools for the personalized assessment of aneurysms from a morphology and fluid dynamics perspective with regard to rupture risk;
  • Created a comprehensive environment for the image-based creation of personalized anatomical models and the assignment of personalized properties for subsequent treatment modeling; deployed in multiple leading hospitals and research labs.


Solutions Beyond State-of-the-Art

IT'IS designs a wide range of RF applicators and exposure systems, as well as ultrasonic transducers for therapeutic applications. IT'IS also supports its partners in the total process of precision medicine from the processing of patient image data, design of applicators and characterization of incident fields to focusing and tuning to minimize collateral damage, modeling of the treatment's intended and unintended effects, and assessment of safety and efficacy.


We look forward to discussing with you how we can best support your R&D initiatives and regulatory submissions – simply call us at +41 44 245 96 96 or send us an email at

Aubry, J.F., Bates, O., Boehm, C., Butts Pauly, K., Christensen, D., Cueto, C., Gélat, P., Guasch, L., Jaros, J., Jing, Y., Jones, R., Li, N., Marty, P., Montanaro, H., Neufeld, E., Pichardo, S., Pinton, G., Pulkkinen, A., Stanziola, A., Thielscher, A., Treeby, B. & van 't Wout, E. Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models. The Journal of the Acoustical Society of America, 152(2):1003-1019, 2022, doi:10.1121/10.0013426
Lemaire, T., Vicari, E., Neufeld, E., Kuster, N. & Micera, S. MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound. iScience, 24(9):103085-103085, 2021, doi:10.1016/j.isci.2021.103085
Montanaro, H., Pasquinelli, C., Lee, H.J., Kim, H., Siebner, H.R., Kuster, N., Thielscher, A. & Neufeld, E. The impact of CT image parameters and skull heterogeneity modeling on the accuracy of transcranial focused ultrasound simulations. Journal of Neural Engineering, 18(4):046041, 2021, doi:10.1088/1741-2552/abf68d
Paulides, M.M., Rodrigues, D.B., Bellizzi, G.G., Sumser, K., Curto, S., Neufeld, E., Montanaro, H., Kok, H.P. & Dobsicek Trefna, H. ESHO benchmarks for computational modeling and optimization in hyperthermia therapy. International Journal of Hyperthermia, 38(1):1425-1442, 2021, doi:10.1080/02656736.2021.1979254
Poni, R., Neufeld, E., Capstick, M., Bodis, S., Samaras, T. & Kuster, N. Feasibility of Temperature Control by Electrical Impedance Tomography in Hyperthermia. Cancers, 13(13):3297, 2021, doi:10.3390/cancers13133297
Lemaire, T., Neufeld, E., Kuster, N. & Micera, S. Understanding Ultrasound Neuromodulation Using a Computationally Efficient and Interpretable Model of Intramembrane Cavitation. Journal of Neural Engineering, 16(4):046007, IOP Publishing, 2019, doi:10.1088/1741-2552/ab1685
Sumser, K., Neufeld, E., Verhaart, R.F., Fortunati, V., Gerda M. Verduijn, , Drizdal, T., Walsum, T.v., Veenland, J.F. & Paulides, M.M. Feasibility and Relevance of Discrete Vasculature Modeling in Routine Hyperthermia Treatment Planning. International Journal of Hyperthermia, 36(1):801-811, Taylor \& Francis, 2019, doi:10.1080/02656736.2019.1641633
Dressel, S., Gosselin, M.C., Capstick, M.H., Carrasco, E., Weyland, M.S., Scheidegger, S., Neufeld, E., Kuster, N., Bodis, S. & Rohrer Bley, C. Novel Hyperthermia Applicator System Allows Adaptive Treatment Planning: Preliminary Clinical Results in Tumour-Bearing Animals. Veterinary and Comparative Oncology, 16(2):202-213, 2018, doi:10.1111/vco.12340
Datta, N.R., Krishnan, S., Speiser, D., Neufeld, E., Kuster, N., Bodis, S. & Hofmann, H. Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's 'magic (nano)bullet' for cancer theranostics? Cancer Treatment Reviews, 50:217-227, 2016
Neufeld, E., Kyriacou, A., Kainz, W. & Kuster, N. Approach to validate simulation-based distribution predictions combining the Gamma-method and uncertainty assessment: application to focused ultrasound. Journal of Verification, Validation and Uncertainty Quantification, 1(3):031006-031006-8, 2016
Kyriakou, A., Neufeld, E., Werner, B., Szekely, G. & Kuster, N. Full-Wave Acoustic and Thermal Modeling of Transcranial Ultrasound Propagation and Investigation of Skull-Induced Aberration Correction Techniques: A Feasibility Study. Journal of Therapeutic Ultrasound, 3(11):1-18, 2015
Murbach, M., Neufeld, E., Christopoulou, M., Achermann, P. & Kuster, N. Modeling of EEG Electrode Artifacts and Thermal Ripples in Human Radiofrequency Exposure Studies. Bioelectromagnetics, 35(4):273-283, 2014
Karampatzakis, A., Kühn, S., Tsanidis, G., Neufeld, E., Samaras, T. & Kuster, N. Antenna Design and Tissue Parameters Considerations for an Improved Modelling of Microwave Ablation in the Liver. Physics in Medicine and Biology, 58(10):3191-3206, 2013, doi:10.1088/0031-9155/58/10/3191
Karampatzakis, A., Kühn, S., Tsanidis, G., Neufeld, E., Samaras, T. & Kuster, N. Heating Characteristics of Antenna Arrays Used in Microwave Ablation: A Theoretical Parametric Study. IEEE Transactions on Biomedical Engineering, 43(10):1321-1327, 2013
Paulides, M., Stauffer, P., Neufeld, E., Maccarini, P., Kyriakou, A., Canters, R., Diederich, C., Bakker, J. & van Rhoon, G. Simulation Techniques in Hyperthermia Treatment Planning. International Journal of Hyperthermia, 29(4):346-357, 2013, doi:10.3109/02656736.2013.790092
Paulides, M., Bakker, J., Linthorst, M., Zee, J.V.d., Rijnen, Z., Neufeld, E., Pattynama, P., Jansen, P., Levendag, P. & van Rhoon, G. The Clinical Feasibility of Deep Hyperthermia Treatment in the Head and Neck: New Challenges for Positioning and Temperature Measurement. Physics in Medicine and Biology, 55(9):2465-2480, 2010, doi:10.1088/0031-9155/55/9/003
Neufeld, E. A New Planning Tool for Hyperthermic Cancer Treatment. ERCIM News(69)pages 31-32, 2007
Paulides, M., Bakker, J., Neufeld, E., Jansen, P., Levendag, P. & van Rhoon, G. The HYPERcollar: A Novel Applicator for Hyperthermia in the Head and Neck. International Journal of Hyperthermia, 23(8):567-576, 2007, doi:10.1080/02656730701670478