o2S2PARC landing page showing various study templates. 


o2S2PARC pipeline for easy connection of services and the organization of workflows.


Example of using a service in the “App Mode", a simplified pipeline interface for non-expert users (e.g. applying iSEG for image segmentation).


o2S2PARC supports the embedding of third-party software (e.g., DSI Studio, an environment for brain tractography analysis).


Jupyter notebooks can be easily used for testing and developing custom Python scripts.


In o2S2PARC, Sim4Life-based modeling, simulation and post-processing can be easily integrated into any pipeline.



With our online computational platform o2S2PARC, researchers can easily transform models and code into configurable, reusable, sustainable, and shareable studies, applications, workflows and services. Users benefit from access to a large number of available modules as well as from the graphical user interface that is integral to o2S2PARC.


One of the main missions of the IT'IS Foundation is to advance research and technology by providing support for the most advanced biomedical simulations. For this mission, we have developed two platforms: Sim4Life (co-developed with ZMT Zurich MedTech AG) and o2S2PARC. Sim4Life is run on powerful desktop computers, while o2S2PARC is built on a new paradigm – an open, cloud-based platform for the development, execution, and sharing of computational models, simulations, and data analysis pipelines, and the presentation of results. All that users require for access to o2S2PARC's powerful computational resources is a web-browser.

o2S2PARC – short for “Open Online Simulations for Stimulating Peripheral Activity to Relieve Conditions” – was originally developed as part of the National Institutes of Health Common Fund’s “Stimulating Peripheral Activity to Relieve Conditions” (SPARC) program. The main goal of the SPARC program is to support the study of therapeutic neuromodulation of the autonomic nervous system. Within the SPARC program, the ultimate goal of o2S2PARC is to enable modeling of bioelectronic medicine applications, from device-level physical interactions with the peripheral nervous system/spinal cord through to the resulting therapeutic effects on organ physiology, while also providing advance warning of potential unwanted side effects.

Our Vision

The IT'IS Foundation, together with Z43 partners, continues work to expand o2S2PARC. Our vision for o2S2PARC encompasses not only the field of bioelectronic medicine, but also its use as the ultimate platform for collaborative, sustainable, reproducible, scalable, open, FAIR (Findable, Accessible, Interoperable and Reusable), and user-extensible computational sciences.

Recently, we have natively implemented Sim4Life in o2S2PARC to create S4L, the web version of Sim4Life, currently available as S4Llite. This important milestone enables the integration of all Sim4Life functionalities – i.e., simulators of tissue responses for physical interactions within complex anatomical environments for medical device/therapy design, personalized medicine, and in silico studies – with other tools in comprehensive pipelines and their deployment as online-accessible, user-friendly applications.

o2S2PARC V1.x

o2S2PARC provides access to dozens of services developed by SPARC researchers and the IT’IS team to facilitate tasks such as image processing and image-based modeling, mechanistic and data-driven biophysical simulation (electromagnetic, electrophysiology, organ physiology, etc.), training and application of deep neural networks, and explorable data analysis and visualization. Those services can be flexibly combined into pipelines and converted into step-by-step guided applications suitable for use by non-expert modellers (e.g., our TIP tool for temporal interference stimulation planning). Studies can easily be shared with other users or converted into publishable templates.

Future Releases

The micro-service technologies used by o2S2PARC to bundle services with their runtime environment ensures that the services continue to function sustainably as the platform evolves and to reproduce the original behavior. Forthcoming functionality will include parameterized modeling, version tracking, enhanced collaboration functionalities, as well as readily usable modules for meta-modeling (optimization, surrogate modeling, inverse problem solving, etc.) and control.

Requests and Inquiries

For further information or to request an o2S2PARC account, please send an email request to support.


o2S2PARC is funded by the NIH Common Fund’s SPARC program under OT3OD025348.

Reference for Citation

Please, cite the use of o2S2PARC in your publications, as follows: “o2S2PARC platform [1], https://osparc.io/”

[1] E. Neufeld et al. SPARC’s Open Online Simulation Platform for Computational Modeling of the ANS’s Physiological Role and its Modulation by Electroceutical Devices: o2S2PARC. The FASEB Journal. 2020,34(S1):1ff, https://doi.org/10.1096/fasebj.2020.34.s1.07491.

SPARC Portal

Check out the SPARC Portal to find out more about SPARC as well as for access to digital resources that can be shared, cited, visualized, computed, and used for virtual experimentation!

Tutorials & Documentation

Videos & Webinars