TI Planning Tool TIP V2.0

At IT’IS, we are committed to supporting innovative, safe, and effective therapies through cutting-edge computational life sciences.

Background

Temporal interference (TI) and its potential to selectively stimulate deep brain regions without activating overlaying structures has recently attracted huge interest and stimulated a large number of animal and human studies.

IT’IS has been inundated with requests from research groups to use our computational modeling tools and expertise to create optimized protocols for planned or ongoing studies. To satisfy that large demand and provide neuroscientists and brain stimulation experts who have little expertise or experience with computational modeling with a tool to their stimulation protocols, IT'IS has developed the TI planning tool, TIP.

The TIP Tool

TIP is a novel online tool powered by o²S²PARC technology that reduces optimization of targeted neurostimulation protocols to three simple steps:

(i) definition of target brain regions and constraints on potential electrode placement,

(ii) identification of an optimized stimulation protocol – based on sophisticated electromagnetic simulations involving detailed anatomical head models, automated multi-goal optimization, and interactive refinement – and export of a detailed report with quantitative and visual information,

(iii) interactive exposure analysis using the powerful functionality of Sim4Life web.

Introduction to the TIP tool.

The choice of exposure parameters optimized with the TIP tool can be used directly for performing experiments with the TIBS-R system of TI Solutions AG.

Latest Release: TIP V2.0

The latest release, TIP V2.0, includes the following important features:

• a comprehensive library of different, highly detailed anatomical head models, complete with precomputed field exposures, enabling inter-subject variability assessment
• a mouse model to facilitate TI research involving rodents
• two new modes, i.e., multichannel TI and phase-modulation TI
• an extended list of brain stimulation targets
• optimal utilization of cloud-computing and parallelization, delivering an interactive user experience for efficient exploration of large stimulation parameter spaces

Demonstration of the features of TIP V2.0.

Future Releases

IT’IS will continue to develop and extend the TIP tool. Foreseen upcoming functionality – based on currently ongoing research of IT’IS and collaborating research groups – will include:

• a further extended field library (more head models, other species, different electrode shapes)
• functionality for subject-specific, image-based modeling (personalized planning)
• a repository of TI stimulation protocols established by different research groups
• more optimization functional flexibility
• brain activity modeling
• surrogate modeling
• additions requested by the users

Request & Inquiries

TIP is available to Sim4Life users and TIBS-R users at no cost (IT'IS Foundation, TI Solutions AG and ZMT). In case of interest, please contact us to obtain access to TIP V2.0. 

For further information, please send us an email or call +41 44 245 9898.

Make sure to also check out the latest version of the TI Brain Stimulator for Research (TIBS-R) from our Z43 partner TI Solutions AG. 

Acknowledgment

We gratefully acknowledge the clinical insights, and critical feedback of the teams of Prof. Grossman (Imperial College) and Prof. Hummel (EPFL).

Reference for Citation

Please, cite the use of TIP in your publications, as follows: "IT'IS Foundation, (2023, August 01), Temporal Interference Planning Tool TIP V2.0. https://tip.itis.swiss"

Disclaimer

By using the TI Planning Tool (TIP) (the "Software"), the End User agrees and acknowledges that the Software is a novel and experimental online tool developed for neuroscientists and brain stimulation experts to determine optimized electrode placement and stimulation conditions for targeting deep brain regions. The Software does not provide binding results and is not a substitute for the expert End User's own calculations of electrode placement and stimulation conditions for targeting deep brain regions. The Software is only intended to assist the expert End User in his/her own calculations. Therefore, the expert End User shall always ascertain the Software's results by doing his/her own calculations. DO NOT ACT SOLELY ON THE RESULTS OF THE SOFTWARE. The expert End User uses the Software and its results at his/her own risk. As a consequence, IT'IS Foundation does not give any representations and warranties for the Software and the liability of IT'IS Foundation in connection with the Software and its use and application is excluded to the full extent possible under the applicable law. IT'IS is not liable for any damages (including without limitation consequential, incidental, direct, indirect, special or punitive damages, damages for loss of profits, loss of use, business interruption, loss of information or data, or pecuniary loss) resulting from the use of or reliance on the Software. In particular, IT'IS Foundation is not responsible for (a) the correctness, completeness, integrity and accuracy of any data calculated by the Software, (b) any conclusions drawn by the End User or any third party from any simulation, calculation, modelling or other process or operation executed by the Software or by End User using the Software, (c) the technical, scientific, legal and commercial feasibility of any project, product and undertaking of the End User or any third party, and (d) the economic and financial viability of any project, product and undertaking of the End User or any third party.
By using the Software, the End User agrees to Swiss material law (excluding conflict of law rules) being applicable and the ordinary Swiss courts of Zurich, Canton of Zurich, having exclusive jurisdiction for all disputes arising out of or in connection with the Software and its use.