Investigating the Mechanisms of Temporal Interference Stimulation

Temporal Interference Stimulation

We are seeking highly motivated Bachelor’s, Semester, and Master’s students to help us uncover the fundamental mechanisms of Temporal Interference Stimulation (TIS), a new form of non-invasive deep brain stimulation based on the targeted interference of two or more high-frequency electromagnetic fields. TIS has already shown significant clinical promise in the treatment of neurological and psychiatric disorders.

We are offering a range of projects aimed at bridging experimental and computational neuroscience to deepen the understanding of how TIS modulates brain activity at the cellular, network, and system level. These projects are ideal for students passionate about neuroscience, neuroengineering, and translational research.

Available Project Topics

• The construction of a representative in vitro model system of living neurons that mirrors the cellular composition of the brain.
• Optical imaging-based studies to investigate TIS mechanisms across various stimulation parameters and neuronal populations.
• TIS investigations using CMOS high-density multi-electrode arrays with living neurons.
• Computational modeling of TIS covering electric field distributions, neuron-electromagnetic field interactions, and network-level simulations using physics-based and data-driven approaches.

Academic Enrollment

Students participating in this collaborative effort between the IT’IS Foundation and ETH Zurich will be enrolled at ETH Zurich in the Laboratory for Biosensors and Bioelectronics (LBB) under the supervision of Prof. Dr. János Vörös.

For more information, visit the LBB website.

What We Offer

• Supervision and mentorship within a multidisciplinary team of experts in computational and experimental neuroscience.
• Integration within the LBB at ETH Zurich, with full access to state-of-the-art facilities for cell culturing and experimental neuroscience.
• Opportunity to contribute to cutting-edge research with clinical relevance.

Who You Are

You are a highly motivated student interested in neuroscience and neurotechnology with a background in electrical engineering, biomedical engineering, computer science, biophysics, neuroscience or related biomedical fields.

Contact

If you are interested in contributing to this research, please send your application with a short statement of motivation, a letter of reference, and your CV to:

• Dr. Fariba Karimi (karimi@itis.swiss)
• Dr. Tobias Ruff (ruff@itis.swiss)
• Dr. Taylor Newton (newton@itis.swiss)

We look forward to hearing from you!