Neuroengineering and Brain Interfaces
Personalization and Optimization
A personalized pipeline that improves EM field simulation accuracy by integrating subject-specific structural information from MRI (T1, T2, DTI) to provide electrode placement coordinates based on multi-goal Pareto optimizations over field quantities of interest.
Personalization and Optimization
Personalized Therapy Planning and Optimization
Inter-individual variability in anatomy and tissue properties (including dielectric heterogeneity and anisotropy) makes reproducible targeting a challenge. We develop efficient tools for stimulation planning and interpretation—including electrode placement, current optimization, and multi-objective (Pareto) analysis—so that targeting improves while off-target modulation is minimized.
Focus Areas
- Personalized planning: Leveraging Sim4Life’s image-based workflows for invasive and noninvasive neuromodulation (including temporal interference stimulation; TIS).
- Personalization at scale: Reducing friction in the workflow—from MRI/DTI segmentation to optimization and protocol export—to make individualized planning routine in research and clinical settings.
- Multi-channel TIS: Designing multi-channel (>2) protocols to further enhance focality and reduce off-target effects (Botzanowski et al., 2025).
Selected Achievements
- End-to-end TIS planning (TIP): A platform to design, compare, and optimize TIS montages (2-channel, multichannel, phase-modulated) under dose and safety constraints, featuring fully automated personalized workflows for diverse anatomical targets.
References
Botzanowski, B. et al., 2025. Focal control of non-invasive deep brain stimulation using multipolar temporal interference. Bioelectron Med 11, 7. https://doi.org/10.1186/s42234-025-00169-6
