Human Cortical Neuron Models – “Aberra” Dataset

The “Aberra” model collection consists of 25 highly detailed, biophysically realistic computational models of human cortical pyramidal neurons. These models are identical to those introduced by Aberra et al. [1] publicly available via the ModelDB [2]. Originally developed by the Blue Brain Project [3,4] to simulate mouse neocortical circuits, these models have been expertly adapted to reflect human neuronal morphology and electrophysiology. They are compatible with Yale’s NEURON simulation environment. To facilitate broader usability, also with Sim4Life, the models have been lightly modified for full compatibility with Sim4Life (ZMT ZurichMedTech AG, Zurich, Switzerland). These edits enable applications that involve the modeling of low-frequency electromagnetic (LF-EM) field interactions with single neurons — as relevant, e.g., when studying bioelectronic medicine and neurostimulation technologies such as:

• Transcranial Direct Current Stimulation (tDCS)
• Transcranial Magnetic Stimulation (TMS)
• Temporal Interference Stimulation (TIS)
• Deep Brain Stimulation (DBS)

Each model includes:

• Realistic dendritic arborizations
• Myelinated and unmyelinated axons
• Associated ion channel dynamics and distributions

This dataset is ideal for researchers investigating mechanisms of interaction underlying neural activation and modulation in response to electric and magnetic fields, particularly on the single cell level.

Additional information:

The downloadable files include:

• a description of the data selection process with a summary of known issues
• the data in hoc format
• ...

References:

[1] Aberra AS, Peterchev AV, Grill WM. Biophysically realistic neuron models for simulation of cortical stimulation. J Neural Eng. 2018 Dec;15(6):066023

[2] https://modeldb.science/241165

[3] Markram H†, Muller E†, Ramaswamy S†, Reimann MW†, Abdellah M, Sanchez CA, Ailamaki A, Alonso-Nanclares L, Antille N, Arsever S et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:2, 456 - 492. doi: 10.1016/j.cell.2015.09.029

[4] Ramaswamy S, Courcol J-D, Abdellah M, Adaszewski SR, Antille N, Arsever S, Atenekeng G, Bilgili A, Brukau Y, Chalimourda A, Chindemi G, Delalondre F, Dumusc R, Eilemann S, Gevaert ME, Gleeson P, Graham JW, Hernando JB, Kanari L, Katkov Y, Keller D, King JG, Ranjan R, Reimann MW, Rössert C, Shi Y, Shillcock JC, Telefont M, Van Geit W, Villafranca Diaz J, Walker R, Wang Y, Zaninetta SM, DeFelipe J, Hill SL, Muller J, Segev I, Schürmann F, Muller EB and Markram H (2015). The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex. Front. Neural Circuits 9:44. doi: 10.3389/fncir.2015.00044

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