Simulation of FUS Induced Blood-Brain-Barrier Opening

Simulation of FUS Induced Blood-Brain-Barrier Opening (PhD)


Zurich, Switzerland
IT'IS Foundation for Research on Information Technologies in Society,
ETH (Swiss Federal Institute of Technology) Zurich

Within the last decade, computational techniques have become increasingly relevant in biomedicine. The IT'IS Foundation employs more than 20 electrical engineers, physicists, and computer engineers; is active in the fields of modeling, electromagnetic exposure, and dosimetric measurements; and is extending its current activities in the field of biomedicine. Together with the ETH and its spin-off SPEAG, IT'IS has developed one of the most advanced TCAD platforms for the numerical simulation of electrodynamic and thermal physics. IT'IS has experience in studying tumor growth and treatments as well as blood-flow-related phenomena.

In this context, we are offering an interesting and socially relevant PhD position with a focus on the simulation of high intensity focused ultrasound (HIFU)-induced opening of the blood-brain barrier and targeted drug delivery – a relatively novel medical technique. The simulation environment to be developed will be capable of computing: ultrasound propagation; micro-bubble cavitation; pressure-induced flow and transport variations; and resulting biological consequences and effects. Interaction with medical and biological experts will be possible, and close contacts with other research groups in the field will have to be maintained throughout the project. Novel numerical techniques and mathematical models will have to be developed and implemented.

The PhD candidate will join a highly motivated and dynamic team working in various related research areas. Furthermore, we work together with prominent research laboratories as well as worldwide leading companies in telecommunications and biomedicine. The work is expected to have a direct impact on the medical application of HIFU in partner hospitals.

We are looking for talented candidates interested in the modeling of biomedical phenomena with theoretical background and a university degree in (medical) physics, mathematics, computer science, material science, electrical/communications engineering or in a similar field. Enhanced knowledge and skills in programming (C/C++/Python) and corresponding tools (Windows and Linux/UNIX based platforms) are recommended.
As soon as possible.
Application Process:  

Applications should consist of:

• a cover letter including the position title and a statement addressing the selection criteria and outlining the motivation for applying for the position
• a detailed CV
• copies of degree certificates and / or diplomas, including grades
• letters of recommendation

We look forward to receiving your complete resume materials as a single pdf file at:

For further information or to discuss the scope of this position, please contact Dr. Esra Neufeld ( or phone +41 44 245 9696).

Contact address:

Charlotte Roberts
IT'IS Foundation
Zeughausstrasse 43
CH-8004 Zurich