The objective of this study was to determine whether the magneto-hemodynamic (MHD) response in a person exposed to the static magnetic field (B0) of a 3T MRI magnet can be used as a diagnostic marker of vascular blood flow. MHD is the surface potential change resulting from the interaction between a strong magnetic field and charged particles in the blood. Blood flow simulations were performed based on boundary conditions derived from MRI flow measurements. The surface potential changes induced over time were obtained from simulations using a specific and thoroughly validated low-frequency electromagnetic solver, and were compared to signals measured with and ECG device. Simulations were performed on the whole-body model of a volunteer. Measurements and simulations results were in excellent agreement for all major signal characteristics. The MHD signal showed strong location dependence with highly variable yet reproducibly measurable characteristics. Additional investigations are necessary to assess its efficacy as a biomarker.
The scientific and technical impact of the study can be summarized as: