Dec 2, 2011

Cancer Cell Proliferation is Inhibited by Specific Modulation Frequencies

Jacquelyn W. Zimmerman, Michael J. Pennison, Ivan Brezovich, Nengjun Yi, Celeste T. Yang, Ryne Ramaker, Devin Absher, Richard M. Myers, Niels Kuster, Frederico P. Costa, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 106, Issue 2, pp. 307–313, January 17, 2012.  Online  December 1, 2011

This paper complements the clinical evidence that low amplitude-modulated electromagnetic fields may elicit therapeutic responses in patients with cancer. Hepatocellular carcinoma (HCC) cells were exposed to the same signals used in in vitro exposure systems designed to replicate in vivo conditions. The modulation frequencies were previously identified by biofeedback methods in patients with a diagnosis of cancer. The control exposure consisted of randomly chosen modulation frequencies within the same 100 Hz–21 kHz range as cancer-specific frequencies. The growth of HCC and breast cancer cells was significantly decreased by HCC-specific and breast cancer-specific modulation frequencies, respectively. However, the same frequencies did not affect proliferation of nonmalignant hepatocytes or breast epithelial cells. Inhibition of HCC cell proliferation was associated with down-regulation of XCL2 and PLP2. The IT'IS Foundation designed and provided the exposure system.

The significances of the paper:

  • Specific cells responded to a weak 27-MHz signal that was AM-modulated with specific frequencies
  • The same cells did not show any response if exposed to the same carrier but with different modulation frequencies
  • If the effect can be independently replicated, this constitutes a major breakthrough in the field of bioelectromagnetics.


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