Gene Expression Changes in Human Cells After Exposure to Mobile Phone Microwaves

Daniel Remondini, Reetta Nylund, Jukka Reivinen, Florence Poulletier de Gannes, Bernard Veyret, Isabelle Lagroye, Emmanuelle Haro, M. Angeles Trillo, Miriam Capri, Claudio Franceschi, Kathrin Schlatterer, Richard Gminski, Rudolf Fitzner, Rudolf Tauber, Jurgen Schuderer, Niels Kuster, Dariusz Leszczynski, Ferdinando Bersani and Christian Maercker, in Proteomics, Published Online: 28 Jul 2006

In a pilot-like study, six human cell types, immortalized cell lines and primary cells, were exposed to 900 and 1800 MHz and analyzed on whole-genome cDNA arrays. NB69 neuroblastoma cells, T lymphocytes, and CHME5 microglial cells did not show significant changes in gene expression. In EA.hy926 endothelial cells, U937 lymphoblastoma cells, and HL-60 leukemia cells between 12 and 34 up- or down-regulated genes were found. Analysis of the affected gene families does not point towards a stress response. However, following microwave exposure, some human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism.

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