Effects of mobile phone type GSM 900MHz signals on the cerebral blood circulation were investigated using near-infrared spectrophotometry in a trial on 16 healthy volunteers. Borderline significant short term responses of oxyhemoglobin and deoxyhemoglobin concentration were observed during exposure, corresponding to a decrease of cerebral blood flow and volume. These were smaller than regular physiological changes and these responses may be spurious and require further study. No dose-response relation or long term response was detected.