Temporal interference (TI) and its potential to selectively stimulate deep brain regions without activating overlaying structures has recently attracted huge interest and stimulated a large number of animal and human studies.
At IT’IS, we have been inundated with requests from research groups to use our computational modeling tools and expertise to create optimized protocols for planned or ongoing studies.
On the one hand, we can hardly keep up with the large demand, but on the other hand, we believe that it would be of great benefit to the field to provide neuroscientists and brain stimulation experts who have no expertise or experience with modeling with a tool to optimize electrode placement and stimulation currents for targeted TI stimulation.
IT'IS has worked hard to develop a solution that is both sophisticated and easy to use, even for non-modeling experts. The result is TIP, a novel online tool powered by o²S²PARC technology that reduces optimization of targeted neurostimulation to three simple steps – as shown in this user video:
(i) Definition of target brain regions and constraints on potential electrode placement
(ii) Identification of an optimized stimulation protocol – based on sophisticated electromagnetic simulations involving detailed anatomical head models, automated multi-goal optimization, and interactive refinement – and export of a detailed report that contains quantitative and visual information
(iii) Interactive exposure analysis using the powerful functionality of Sim4Life:web
More advanced studies are possible by exporting the configurations to Sim4Life. If needed, our experts are always available to explore more advanced configurations in more detail.
The benefits and features of TIP V1.0 are manifold:
Features that will be included in forthcoming versions:
Request a login to TIP V1.0 from our website.
Make sure you also check out the latest TI Brain Stimulator for Research (TIBS-R) from our Z43 partner TI Solutions AG.
At IT’IS, we are committed to supporting innovative, safe, and effective therapies through leading-edge computational life sciences.
For further information, please email us or call +41 44 245 9696.
The IT’IS Team