Professor Colleen E. Clancy of the Department of Pharmacology, School of Medicine and Associate Vice Chancellor for Academic Personnel at the University of California Davis was a guest speaker in the IT'IS Brown-Bag-Lunch Seminar series on Wednesday, September 12, 2018. In her presentation entitled "Computational cardiology from the atom to the rhythm", , Prof. Clancy gave a fascinating overview on multiscale modeling of cardiac electrophysiology and, in a stimulating discussion round, she presented her views on verification, validation, and uncertainty quantification in computational life sciences.
Prof. Clancy was visiting IT'IS to brainstorm on computational modeling in the context of the US National Institutes of Health (NIH) Common Fund’s initiative Stimulating Peripheral Activity to Relieve Conditions (SPARC). The SPARC program was launched to advance neuromodulation technologies through better understanding of nerve-organ interactions towards realizing precision therapies to augment or replace conventional medical treatments. IT'IS is contributing to this research initiative with the project Open Platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions (o2S2PARC), the development of an open-source platform to host all computational models developed within SPARC.
Prof. Clancy is a principal investigator on a SPARC project to develop a new suite of computational tools to simulate neuromodulation of cardiac and vascular function. Her BBL presentation on multiscale modeling of cardiac electrophysiology fascinating and, in a stimulating discussion round, she presented her views on verification, validation, and uncertainty quantification in computational life sciences. Her cardiac myocyte and cardiac tissue models are among the first to have been ported to the o2S2PARC platform, and continuing collaboration is planned to include more models as they are developed.