IT'IS Annual Report 2023

The annual report of the IT'IS Foundation for 2023 has been published. It includes a summary of the research efforts focused on devising the first solution for assessment of absorbed power density, as well as information on current projects, key figures and infrastructure, selected publications, our team, the board members, and selected partners and sponsors.

TyProxi's Research Findings Lead to a Commercial Test System

Results of the successful collaboration between IT’IS and Semtech on the project “TyProxi” has led to the development of a new module for reliable evaluation of time-averaged proximity sensors.

First Commercial Cloud-Based Platform Powered by o²S²PARC

IT'IS computational platform enables ZMT to release Sim4Life.web, a web-based version of their advanced commercial Sim4Life desktop computational platform.

Causal Phase-Dependent Control of Non-Spatial Attention in Human Prefrontal Cortex (Nat. Hum. Behav.)

Jeroen Brus, Joseph A. Heng, Valeriia Beliaeva, Fabian Gonzalez Pinto, Antonino M. Cassarà, Esra Neufeld, Marcus Grueschow, Lukas Imbach, and Rafael Polanía, Nature Human Behaviour 2024, online 16 February 2024; doi: 10.1038/s41562-024-01820-z

Causal Phase-Dependent Control of Non-Spatial Attention in Human Prefrontal Cortex

New High-End Filters for Concurrent HD-EEG Recording and TI Stimulation

Many research groups would like to perform closed-loop temporal interference stimulation studies. IT’IS has developed brand new filters specifically for the TI Solutions’ TIBS-R device (currently available for Electrical Geodesics, Inc. and BrainProducts electroencephalography systems) that allow uncompromised high-density encephalogram recordings during stimulation.

Zurich43 Retreat 2024: Demarcation of Tolerance

In mid-February, the annual Z43 retreat was held at the Hotel Pilatus Kulm to discuss the timely topic of “Demarcation of Tolerance in Science, Society and the Individual” with the goal to better understand the importance and limitations of tolerance.

2024 Call for Applications: Katja Poković Research Fellowship

The call for applications for the 2024 Katja Poković Research Fellowship is now open.

SEAWave 4th General Assembly in Rome, Italy

The 4^th General Assembly of the Project SEAWave took place on February 5 – 6, 2024, in Rome, Italy.

IT’IS and Z43 partners host researchers from Taiwan

During the last two weeks, IT’IS, jointly with Z43 partners, had the great pleasure of hosting researchers from the National Yang Ming Chiao Tung University Taiwan and Auden Techno. Corp, Taiwan.

2024 NANS Abstract Award Winner

The abstract entitled "Computational Pipeline for Modeling Ultrasound Propagation and Electrophysiological Impacts for Non-invasive Peripheral Nervous System Stimulation" was awarded an oral abstract award at NANS 2024, presented by Lucia Moya Sans.

TIP V2.2: Enhanced Target Selection and Precision for TI Research

The newly released Version 2 of our Temporal Interference Planning Tool supports multi-channel TI and phase modulation, human inter-subject variability assessment, and includes four head anatomies and a rodent computational anatomical model. TIP V2.0 also supports all features of TIBS-R V2.0.

SENS-THERM Kick-Off Meeting in Rotterdam

Last week, team members from Z43, Sensius B.V., TU/e and Erasmus MC met in Rotterdam to kick off the Eurostars project SENS-THERM.

TI Stimulation: A Promising New Technology For Treating Brain Diseases

Non-Invasive Temporal Interference Electrical Stimulation of the Human Hippocampus (Nat. Neurosci.)

Ines R. Violante, Ketevan Alania, Antonino M. Cassarà, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L. Kurtin, Edward Rhodes, Adam Hampshire, Niels Kuster, Edward S. Boyden, Alvaro Pascual-Leone, and Nir Grossman, Nature Neuroscience 2023, online 19 October 2023; doi: 10.1038/s41593-023-01517-y

Noninvasive Theta Burst Stimulation of The Human Striatum Enhances Striatal Activity and Motor Skill Learning (Nat. Neurosci.)

Maximilian J. Wessel, Elena Beanato, Traian Popa, Fabienne Windel, Pierre Vassiliadis, Pauline Menoud, Valeriia Beliaeva, Ines R. Violante, Hedjoudje Abderrahmane, Patrycja Dzialecka, Chang-Hyun Park, Pablo Maceira-Elvira, Takuya Morishita, Antonino M. Cassarà, Melanie Steiner, Nir Grossman, Esra Neufeld, and Friedhelm C. Hummel, Nature Neuroscience 2023, online 19 October 2023; doi: 10.1038/s41593-023-01457-7

IT’IS Co-Hosts Webinar “From Models to Heartbeats”

Influence of patient head definition on induced E-fields during MR examination (Magn. Reson. Med.)

Tolga Goren, Sylvain Reboux, Silvia Farcito, Bryn Lloyd and Niels Kuster, Magnetic Resonance in Medicine 2023, online 18 October 2023; doi: 10.1002/mrm.29894

Influence of Patient Head Definition on Induced E-fields during MR Examination

itis.swiss: Our All-New Mobile-Optimized Landing Page

Our new landing page comes with a fresh and contemporary look, an enhanced user experience, and is based on a fully responsive "mobile first" design, ensuring optimal presentation across all device types.

Posable Pig V1.1: Male Pig Anatomical Model Overhaul

Z43 Glowing Night

o²S²PARC Year 7 Award for IT’IS

IT’IS is proud to announce the award of a 7^th year of funding for its o²S²PARC computational platform under the NIH SPARC program.

Obstructive Sleep Apnea Improves with Non‑invasive Hypoglossal Nerve Stimulation Using Temporal Interference (Bioelectron. Med.)

Florian Missey, Malin Silverå Ejneby, Ibrahima Ngom, Mary J. Donahue, Jan Trajlinek, Emma Acerbo, Boris Botzanowski, Antonino M. Cassarà, Esra Neufeld, Eric D. Glowacki, Lee Shangold, William M. Hanes and Adam Williamson, Bioelectronic Medicine 2023, Volume 9, Article No. 18, online 09 August 2023; doi: 10.1186/s42234-023-00120-7

Successful Wrap-Up of the Horizon 2020 Project NeuHeart

TIP V2.0 – Multichannel and Phase-Modulation TI

The newly released Version 2 of our Temporal Interference Planning Tool supports multi-channel TI and phase modulation, human inter-subject variability assessment, and includes four head anatomies and a rodent computational anatomical model. TIP V2.0 also supports all features of TIBS-R V2.0.

TIBS-R V2.0: Phase Modulation and Enhanced Reliability

We are pleased to announce the release of TIBS-R V2.0 from IT’IS partner TI Solutions AG. This upgrade makes the device not only more reliable but also supports multi-channel phase modulation, which broadens the range of possible experimental conditions by enabling non-invasive stimulation of deep brain targets with complex interference waveforms.

Visiting Scientist and "Brown Bag Lunch" Seminar Series

Dr. Florian Missey, from the International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC), Brno, Czech Republic, visited Z43 for a week to discuss our ongoing research collaboration and participated as guest speaker in Z43’s Brown Bag Lunch seminar series.

SEAWave Consortium Meeting in Paris

The third consortium meeting of the SEAWave project, hosted by ANFR, was held in Paris, France, in early July.

Efficient Prediction of MRI Gradient-Induced Heating for Guiding Safety Testing of Conductive Implants (Magn. Reson. Med.)

Umberto Zanovello, Carina Fuss, Alessandro Arduino, and Oriano Bottauscio, Magnetic Resonance in Medicine 2023, Volume 90, online 29 June 2023; doi: 10.1002/mrm.29787

Soft-X-Ray Confined-Electron Laser (Phys. Rev. A)

Arya Fallahi, Niels Kuster, and Lukas Novotny, Phys. Rev. A, Volume 107, Issue 6, Article No. L061504, online 28 June 2023; doi: 10.1103/PhysRevA.107.L061504

MRIxViP V2.2: Enhanced Patient Coverage and Fidelity

The IT’IS precomputed library of radiofrequency-induced electromagnetic field distributions inside the human body has been further expanded. The latest release of MRIxViP V2.2 contains two additional human anatomies for better population coverage.