NeuroRat V4.0 – Detailed Rat Anatomy for Neuromodulation Investigations
IT’IS has released NeuroRat V4.0, the first neuro-functionalized animal model. The new whole-body model has been created as part of o2S2PARC, a project funded by the NIH Common Fund’s Stimulating Peripheral Activity to Relieve Conditions (SPARC) program. The anatomy of NeuroRat V4.0 has been segmented from structural magnetic resonance imaging and computed tomography image data that has been acquired by the Animal Imaging Center of ETH Zurich and the University of Zurich.
NeuroRat V4.0 includes 179 tissues and functionalized nerve trajectories for neuromodulation investigations. For noncommercial applications, it can be enriched with a co-registered version of the Waxholm Space Atlas of the Sprague Dawley Rat Brain for enhanced neuroanatomical analysis.
NeuroRat V4.0 has been enhanced by additional Sim4Life functions, such as the poser and automated tissue assignment, and is optimized for the platform in general. It also comes with pre-assigned material properties that are based on the IT’IS Tissue Properties Database.
As of this week, a new whole body pediatric numerical simulation model of a 29-month-old boy is available in our extended Virtual Population (ViP) library. MARTIN V1.0 was developed by the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital, Boston, USA, and will be hosted by IT’IS. We are also pleased to announce the release of the IT’IS ViP Hand Library specifically designed for evaluation of wireless power transfer systems.
Laura Ellen Birks, Luuk Van Wel, Ilaria Liorni, Livia Pierotti, Mònica Guxens, Anke Huss, Milena Foerster, Myles Capstick, Marloes Eeftens, Hanan El Marroun, Marisa Estarlich, Mara Gallastegi, Llúcia González Safont, Wout Joseph, Loreto Santa-Marina, Arno Thielens, Maties Torrent, Tanja Vrijkotte, Joe Wiart, Martin Röösli, Elisabeth Cardis, Roel Vermeulen, and Martine Vrijheid, Environmental Research, Volume 193, February 2021, 110505, online 24 November 2020; doi: 10.1016/j.envres.2020.110505
Alba Cabré-Riera, Luuk van Wel, Ilaria Liorni, Arno Thielens, Laura Ellen Birks, Livia Pierotti, Wout Joseph, Llucia Gonzalez, Jesús Ibarluzea, Amparo Ferrero, Anke Huss, Joe Wiart, Loreto Santa-Marina, Maties Torrent, Tanja Vrijkotte, Myles Capstick, Roel Vermeulen, Martine Vrijheid, Elisabeth Cardis, Martin Röösli, Mònica Guxens, International Journal of Hygiene and Environmental Health, Volume 231, 113659, online 19 November 2020; doi: 10.1016/j.ijheh.2020.113659
Isha Gupta, Antonino M. Cassara, Ilya Tarotin, Matteo Donega, Jason A. Miranda, David M. Sokal, Sebastien Ouchouche, Wesley Dopson, Paul Matteucci, Esra Neufeld, Matthew A. Schiefer, Alison Rowles, Paul McGill, Justin Perkins, Nikola Dolezalova, Kourosh Saeb-Parsy, Niels Kuster, Refet Firat Yazicioglu, Jason Witherington, and Daniel J. Chew, Communications Biology 2020, Volume 3, 577, online 16 October 2020; doi: 10.1038/s42003-020-01299-0
Xiaoyu Liu, Micha Dehler, and Arya Fallahi, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 2020, Volume 986, 11 January 2021, 164722, online 12 October 2020; doi: 10.1016/j.nima.2020.164722
It’s been a challenge, but we made it: after several months of intensive work, we are excited to pre-announce our newly developed investigational stimulator prototype device for temporal interference brain research.
The o2S2PARC project continues to remain a priority at the IT’IS Foundation. The project focuses on building a comprehensive, freely accessible, intuitive, and interactive online platform to simulate peripheral nerve system neuromodulation and its impact on organ physiology in a precise and predictive manner.
IT’IS has released Miss Able V3.0, the first full-body monkey computational anatomical model. The new model features detailed nerve segmentations for all of the major peripheral nerves in the entire body and has more than 300 different individual tissue classes.
Jana Zielinski, Angélique D. Ducray, Anja M. Moeller, Manuel Murbach, Niels Kuster, and Meike Mevissen, Toxicology in Vitro 2020, Volume 68, October 2020, 104963, online 8 August 2020; doi: 10.1016/j.tiv.2020.104963
IT’IS is getting greener! We have installed a new energy system consisting of solar panels and a groundwater-based heat pump. We are proud that we have started to generate our own power and have become largely CO2-free.
Alba Cabré-Riera, Hanan El Marroun, Ryan Muetzel, Luuk van Wel, Ilaria Liorni, Arno Thielens, Laura Ellen Birks, Livia Pierotti, Anke Huss, Wout Joseph, Joe Wiart, Myles Capstick, Manon Hillegers, Roel Vermeulen, Elisabeth Cardis, Martine Vrijheid, Tonya White, Martin Röösli, Henning Tiemeier, and Mònica Guxens, Environment International, Volume 142, 2020, online 15 June 2020; doi: 10.1016/j.envint.2020.105808
Cristina Pasquinelli, Hazael Montanaro, Hyunjoo Jenny Lee, Lars G. Hanson, Hyungguk Kim, Niels Kuster, Hartwig R Siebner, Esra Neufeld and Axel Thielscher, Journal of Neural Engineering, 2020, Volume 17, Issue 4, 046010, online 2 June 2020; doi: 10.1088/1741-2552/ab98dc
Xenios Milidonis, Muhummad Sohaib Nazir, Torben Schneider, Myles Capstick, Sita Drost, Gertjan Kok, Nikola Pelevic, Christian Poelma, Tobias Schaeffter, and Amedeo Chiribiri, Magnetic Resonance in Medicine 2020, Volume 84, Issue 5, online 19 May 2020; doi: 10.1002/mrm.28296
The IT'IS Foundation is responding to the outbreak of COVID-19 with a combination of home office and social distancing measures to protect the safety of employees and their loved ones. IT'IS is keeping disruption to a minimum while maintaining core operations to be able to meet all commitments without delay.
David Schuermann, Christina Ziemann, Zeinab Barekati, Myles Capstick, Antje Oertel, Frauke Focke, Manuel Murbach, Niels Kuster, Clemens Dasenbrock, and Primo Schär, Genes 2020, Volume 11, Issue 4, 347, online 25 March 2020; doi: 10.3390/genes11040347